A prolonged Delta SARS-CoV-2 infection during the Omicron wave in an HIV immunosuppressed patient

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URI: https://hdl.handle.net/20.500.14968/246
E-ISSN: 1878-3511
DOI: 10.1016/j.ijid.2025.108233

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2025-12-20

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Abstract

Here, we describe a fatal, prolonged Delta SARS-CoV-2 infection lasting 55 days during the Omicron wave in a severely immunosuppressed HIV patient. We observed persistent viral replication, high within-host mutation rates, and emergence of rare spike mutations. Findings suggest prolonged infections may drive SARS-CoV-2 evolution and reintroduce variants presumed extinct into immune-evasive forms. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

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SARS-CoV-2Immunosuppressed patientViral variantsProlonged infection

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García-Martínez de Artola, D., Ciuffreda, L., Lorenzo-Salazar, J. M., Muñoz-Barrera, A., González-Montelongo, R., Rodríguez-García, N., Alcoba-Florez, J., Abella-Vazquez, L., Melón, S., & Flores, C. (2026). A prolonged Delta SARS-CoV-2 infection during the Omicron wave in an HIV immunosuppressed patient. International Journal of Infectious Diseases, 162. https://doi.org/10.1016/j.ijid.2025.108233

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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International